| Saturday, 11 September, 2021 |
| Villarreal |
23:30 |
Alaves |
| Sunday, 12 September, 2021 |
| Sevilla |
02:00 |
Barcelona |
| Sunday, 17 October, 2021 |
| Granada |
07:00 |
Atlético de Madrid |
| Real Madrid |
07:00 |
Athletic Bilbao |
| Friday, 29 October, 2021 |
| Celta Vigo |
00:00 |
Real Sociedad |
| Granada |
01:00 |
Getafe |
| Levante |
02:30 |
Atlético de Madrid |
| Saturday, 30 October, 2021 |
| Elche |
19:00 |
Real Madrid |
| Sevilla |
21:15 |
Osasuna |
| Valencia |
23:30 |
Villarreal |
| Sunday, 31 October, 2021 |
| Barcelona |
02:00 |
Alaves |
| Cadiz |
21:00 |
Mallorca |
| Atlético de Madrid |
23:15 |
Real Betis |
| Monday, 1 November, 2021 |
| Getafe |
01:30 |
Espanyol |
| Real Sociedad |
04:00 |
Athletic Bilbao |
| Tuesday, 2 November, 2021 |
| Rayo Vallecano |
01:30 |
Celta Vigo |
| Levante |
04:00 |
Granada |
| Saturday, 6 November, 2021 |
| Athletic Bilbao |
04:00 |
Cadiz |
