| Thursday, 28 October, 2021 |
| OGC Nice |
02:00 |
Marseille |
| Saturday, 30 October, 2021 |
| Paris Saint-Germain |
02:00 |
LOSC Lille Métropole |
| Metz |
22:00 |
Saint-Etienne |
| Sunday, 31 October, 2021 |
| Lyon |
02:00 |
Lens |
| Angers |
20:00 |
OGC Nice |
| Girondins de Bordeaux |
22:00 |
Stade de Reims |
| Montpellier Hérault SC |
22:00 |
Nantes |
| Strasbourg |
22:00 |
Lorient |
| ESTAC |
22:00 |
Stade Rennais FC |
| Monday, 1 November, 2021 |
| Brest |
00:00 |
Monaco |
| Clermont |
03:45 |
Marseille |
| Saturday, 6 November, 2021 |
| Lens |
04:00 |
ESTAC |
| Sunday, 7 November, 2021 |
| LOSC Lille Métropole |
00:00 |
Angers |
| Girondins de Bordeaux |
04:00 |
Paris Saint-Germain |
