| Saturday, 11 December, 2021 |
| FC Cologne |
02:30 |
Augsburg 1907 |
| Bayern Munich |
21:30 |
Mainz |
| RB Leipzig |
21:30 |
Borussia Mönchengladbach |
| SC Freiburg |
21:30 |
TSG 1899 Hoffenheim |
| Hertha Berlin |
21:30 |
Arminia Bielefeld |
| VFL Bochum |
21:30 |
Borussia Dortmund |
| Sunday, 12 December, 2021 |
| Wolfsburg |
00:30 |
Stuttgart |
| Greuther Fürth |
21:30 |
Union Berlin |
| Eintracht Frankfurt |
23:30 |
Bayer 04 Leverkusen |
| Wednesday, 15 December, 2021 |
| Stuttgart |
00:30 |
Bayern Munich |
| Arminia Bielefeld |
02:30 |
VFL Bochum |
| Mainz |
02:30 |
Hertha Berlin |
| Wolfsburg |
02:30 |
FC Cologne |
| Thursday, 16 December, 2021 |
| Borussia Mönchengladbach |
00:30 |
Eintracht Frankfurt |
| Borussia Dortmund |
02:30 |
Greuther Fürth |
| Bayer 04 Leverkusen |
02:30 |
TSG 1899 Hoffenheim |
| Union Berlin |
02:30 |
SC Freiburg |
| Augsburg 1907 |
02:30 |
RB Leipzig |
| Saturday, 18 December, 2021 |
| Bayern Munich |
02:30 |
Wolfsburg |
